I noticed Marsten has a Biotech Universe Filter in his mean reversion systems. Discussing with Nick he said it was due to non FDA approval for a drug in testing having a massive impact on the stock at the next days open, which makes sense.
However, like many things that make sense, I tested on my MR and MOC systems and removing Biotech had a negligible impact on the bottom line. If anything it was adverse on the Swing system, which is where I would expect to see the most impact as you might well have been holding a stock doing well only to find it crashing whilst you are holding it.
I also tested on my Momentum system and again, minimal if adverse impact.